5 HT1B Receptor

A Serotonin receptor subtype found at high levels in the Basal Ganglia and the frontal cortex. It plays a Role as a terminal Autoreceptor that regulates the rate of Serotonin release from Nerve Endings. This Serotonin receptor subtype is closely related to and has similar drug binding properties as the 5-HT1D Receptor. It is particularly sensitive to the agonist Sumatriptan and may be involved in mediating the drug's antimigraine effect.