5 HT1D Receptor

A Serotonin receptor subtype that is localized to the Caudate Nucleus; Putamen; the Nucleus Accumbens; the Hippocampus, and the Raphe Nuclei. It plays a Role as a terminal Autoreceptor that regulates the rate of Serotonin release from Nerve Endings. This Serotonin receptor subtype is closely related to and has similar drug binding properties as the 5-HT1B Receptor, but is expressed at low levels. It is particularly sensitive to the agonist Sumatriptan and may be involved in mediating the drug's antimigrane effect.