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6 Methylcompactin

A fungal metabolite isolated from Cultures of Aspergillus terreus. The compound is a potent anticholesteremic agent. It inhibits 3-hydroxy-3-methylglutaryl coenzyme A Reductase (Hydroxymethylglutaryl CoA Reductases), which is the rate-limiting enzyme in Cholesterol biosynthesis. It also stimulates the production of low-density Lipoprotein Receptors in the liver.