An allosteric enzyme that regulates Glycolysis by catalyzing the Transfer of a phosphate group from ATP to Fructose-6-phosphate to yield Fructose-1,6-bisphosphate. D-tagatose- 6-phosphate and sedoheptulose-7-phosphate also are acceptors. UTP, CTP, and ITP also are donors. In Human phosphofructokinase-1, three types of subunits have been identified. They are Phosphofructokinase-1, Muscle Type; Phosphofructokinase-1, Liver Type; and Phosphofructokinase-1, Type C; found in Platelets, Brain, and other Tissues.