abl Genes

Retrovirus-associated DNA sequences (abl) originally isolated from the Abelson murine leukemia virus (Ab-MuLV). The Proto-Oncogene abl (c-abl) codes for a protein that is a member of the Tyrosine Kinase Family. The Human c-abl Gene is located at 9q34.1 on the long arm of Chromosome 9. It is activated by translocation to bcr on Chromosome 22 in Chronic Myelogenous Leukemia.