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Acid Modulators, gamma-Aminobutyric

Substances that do not act as agonists or antagonists but do Affect the gamma-Aminobutyric Acid Receptor-ionophore complex. GABA-A Receptors (Receptors, GABA-A) appear to have at least three Allosteric Sites at which modulators act: a site at which Benzodiazepines act by increasing the opening frequency of gamma-Aminobutyric Acid-activated Chloride Channels; a site at which Barbiturates act to prolong the duration of channel opening; and a site at which some Steroids may act. General Anesthetics probably act at least partly by potentiating GABAergic responses, but they are not included here.