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Acid, trans-Retinoic

An important regulator of Gene Expression during Growth and Development, and in Neoplasms. Tretinoin, also known as retinoic acid and derived from maternal Vitamin A, is essential for normal Growth; and Embryonic Development. An excess of tretinoin can be teratogenic. It is used in the treatment of Psoriasis; Acne Vulgaris; and several other Skin Diseases. It has also been approved for use in promyelocytic Leukemia (Leukemia, Promyelocytic, Acute).