Activity, Nonsuppressible Insulinlike

A Blood protein (NSILA) which mimics the biological activity of Insulin in Serum, but is not suppressed by Insulin Antibodies. During acid-Ethanol extraction of Cohn fraction III, 10% of the activity is found in the supernatant (NSILA-S) and the remaining activity in the precipitate (NSILA-P). The latter is a large molecular compound, much less stable than the soluble fraction. NSILA-S is a more potent Growth factor than Insulin and Exhibits sulfation activity.