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Acyltransferase, Phosophatidylcholine-Sterol

An enzyme secreted from the liver into the Plasma of many mammalian species. It catalyzes the Esterification of the hydroxyl group of Lipoprotein Cholesterol by the Transfer of a fatty acid from the C-2 position of Lecithin. In familial Lecithin:Cholesterol Acyltransferase Deficiency Disease, the absence of the enzyme results in an excess of unesterified Cholesterol in Plasma. EC 2.3.1.43.