ADP-Ribosyltransferase, NAD-Arginine

An enzyme that catalyzes the Transfer of the ADP-Ribose moiety from NAD+ or NADP+ to specific protein substrates with Arginine, Arginine-type compounds, Agmatine, or Guanidine as acceptors. This mono-ADP-ribosylation reaction is the mechanism of action common to several Bacterial Toxins affecting profound changes in cellular Metabolism, such as activation of Adenylate Cyclase, Regulation of protein synthesis at the level of Elongation Factor 2, and Ion Transport across biological Membranes.