Adrenergic Receptors, alpha-2

A subclass of alpha-Adrenergic Receptors found on both presynaptic and postsynaptic Membranes where they signal through Gi-Go G-Proteins. While postsynaptic alpha-2 receptors play a traditional Role in mediating the effects of Adrenergic Agonists, the subset of alpha-2 receptors found on presynaptic Membranes signal the Feedback Inhibition of Neurotransmitter release.