Agouti Signaling Protein

A secreted protein of approximately 131 Amino Acids (depending on species) that regulates the synthesis of eumelanin (brown/black) pigments in Melanocytes. Agouti protein antagonizes the signaling of Melanocortin Receptors and has wide distribution including Adipose Tissue; Gonads; and Heart. Its overexpression in agouti Mice results in uniform yellow coat Color, Obesity, and metabolic defects similar to type II diabetes in Humans.