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alpha-Hydroxylase, Sterol 12

A liver microsomal Cytochrome P450 enzyme that catalyzes the 12-alpha-Hydroxylation of a broad spectrum of Sterols in the presence of molecular Oxygen and NADPH-Ferrihemoprotein Reductase. This enzyme, encoded by CYP8B1gene, converts 7-alpha-hydroxy-4-cholesten-3-one to 7-alpha-12-alpha-dihydroxy-4-cholesten-3-one and is required in the synthesis of Bile Acids from Cholesterol.