alpha Melanocyte Stimulating Hormone

A 13-amino acid peptide derived from proteolytic cleavage of Adrenocorticotropic Hormone, the N-terminal segment of ACTH. ACTH (1-13) is amidated at the C-terminal to form ACTH (1-13)NH2 which in turn is acetylated to form alpha-MSH in the Secretory Granules. Alpha-MSH stimulates the synthesis and distribution of Melanin in Melanocytes in Mammals and Melanophores in lower Vertebrates.