alpha Receptors, Interferon

A ubiquitously expressed heterodimeric receptor that is specific for both Interferon-alpha and Interferon-beta. It is composed of two subunits referred to as IFNAR1 and IFNAR2. The IFNAR2 subunit is believed to serve as the ligand-binding chain; however both chains are required for Signal Transduction. The Interferon alpha-beta receptor signals through the action of Janus Kinases such as the TYK2 Kinase.