alpha4beta1, Integrin Heterodimer

Integrin alpha4beta1 is a Fibronectin and VCAM-1 receptor present on Lymphocytes; Monocytes; Eosinophils; NK Cells and Thymocytes. It is involved in both Cell-Cell and Cell- Extracellular Matrix adhesion and plays a Role in Inflammation, hematopoietic Cell homing and immune function, and has been implicated in skeletal Myogenesis; Neural Crest migration and proliferation, Lymphocyte maturation and Morphogenesis of the Placenta and Heart.