alphaIIbbeta3, Integrin

Platelet Membrane Glycoprotein complex important for Platelet adhesion and aggregation. It is an integrin complex containing Integrin alphaIIb and Integrin beta3 which recognizes the Arginine-Glycine-Aspartic Acid (RGD) sequence present on several Adhesive Proteins. As such, it is a receptor for Fibrinogen; von Willebrand Factor; Fibronectin; Vitronectin; and Thrombospondins. A deficiency of GPIIb-IIIa results in Glanzmann Thrombasthenia.