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Aminolevulinic Acid Synthetase

An enzyme of the Transferase class that catalyzes condensation of the succinyl group from succinyl coenzyme A with Glycine to form delta-aminolevulinate. It is a pyridoxyal phosphate protein and the reaction occurs in Mitochondria as the first step of the Heme Biosynthetic Pathway. The enzyme is a key regulatory enzyme in Heme biosynthesis. In liver Feedback is inhibited by Heme. EC 2.3.1.37.