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Aminotransferase, Tyrosine

An enzyme that catalyzes the conversion of L-Tyrosine and 2-oxoglutarate to 4-hydroxyphenylpyruvate and L-GLUTAMATE. It is a Pyridoxal-phosphate protein. L-Phenylalanine is hydroxylated to L-Tyrosine. The mitochondrial enzyme may be identical with Aspartate Aminotransferases (EC 2.6.1.1.). Deficiency of this enzyme may cause type II Tyrosinemia (see Tyrosinemias). EC 2.6.1.5.