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Anaphylatoxins

Serum Peptides derived from certain cleaved Complement Proteins during Complement Activation. They induce smooth Muscle Contraction; Mast Cell Histamine Release; Platelet Aggregation; and act as mediators of the local inflammatory process. The order of anaphylatoxin activity from the strongest to the weakest is C5a, C3a, C4a, and C5a des-Arginine.