Anchor Proteins, A-Kinase

A structurally-diverse Family of intracellular-signaling adaptor Proteins that selectively tether specific Protein Kinase A subtypes to distinct subcellular sites. They play a Role in focusing the Protein Kinase A activity toward relevant substrates. Over fifty members of this Family exist, most of which bind specifically to regulatory subunits of Cyclic AMP-Dependent Protein Kinase Type II such as cAMP Protein Kinase RIIalpha or cAMP Protein Kinase RIIbeta.