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Angiomatoses, Familial Cerebello-Retinal

An autosomal dominant disorder caused by Mutations in a Tumor Suppressor Gene. This Syndrome is characterized by abnormal Growth of small Blood Vessels leading to a host of Neoplasms. They include Hemangioblastoma in the Retina; Cerebellum; and SPINAL CORD; Pheochromocytoma; pancreatic Tumors; and Renal Cell Carcinoma (see Carcinoma, Renal Cell). Common clinical signs include Hypertension and neurological dysfunctions.