Angiopoietin 2

An angiopoietin that is closely related to Angiopoietin-1. It binds to the TIE-2 Receptor without receptor stimulation and antagonizes the effect of Angiopoietin-1. However its antagonistic effect may be limited to Cell receptors that occur within the vasculature. Angiopoietin-2 may therefore play a Role in Down-Regulation of Blood Vessel branching and sprouting.