Anti Neutrophil Cytoplasmic Antibodies

Autoantibodies directed against cytoplasmic constituents of Polymorphonuclear Leukocytes and/or Monocytes. They are used as specific markers for Wegener Granulomatosis and other Diseases, though their pathophysiological Role is not clear. ANCA are routinely detected by indirect immunofluorescence with three different patterns: c-ANCA (cytoplasmic), p-ANCA (perinuclear), and atypical ANCA.