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Antigen, CD118

A receptor subunit that combines with Cytokine Receptor gp130 to form the dual specificity receptor for Leukemia Inhibitory Factor and Oncostatin M. The subunit is also a component of the Ciliary Neurotrophic Factor Receptor. Both Membrane-bound and secreted Isoforms of the receptor subunit exist due to Alternative Splicing of its mRNA. The secreted isoform is believed to act as an inhibitory receptor, while the Membrane-bound form is a signaling receptor.