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Antigen, CD33

A 67-kDa Sialic Acid binding lectin that is specific for Myeloid Cells and Monocyte-Macrophage Precursor Cells. This protein is the smallest Siglec subtype and contains a single Immunoglobulin C2-set domain. It may play a Role in intracellular signaling via its interaction with SHP-1 Protein-Tyrosine Phosphatase and SHP-2 Protein-Tyrosine Phosphatase.