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Antigen, Cystic Fibrosis

A 10.8-kDa member of the S-100 Family of Calcium-Binding Proteins that can form homo- or heterocomplexes with Calgranulin B and a variety of other Proteins. The Calgranulin A/B heterodimer is known as Leukocyte L1 Antigen Complex. Calgranulin A is found in many Cell types including Granulocytes; Keratinocytes; and myelomonocytes, and has been shown to act as a chemotactic substance for Neutrophils. Because it is present in acute Inflammation but absent in chronic Inflammation, it is a useful Biological Marker for a number of pathological conditions.