Antigens, CD40
Synonyms
Antigen, CD40
Antigen, CDw40
CD40 Antigen
CD40 Antigens
CDw40 Antigen
Receptor, TNFRSF5
TNFRSF5 Receptor
Tumor Necrosis Factor Receptor Superfamily, Member 5
A member of the tumor necrosis factor receptor superfamily with specificity for CD40 LIGAND. It is found on mature B-LYMPHOCYTES and some EPITHELIAL CELLS, lymphoid DENDRITIC CELLS. Evidence suggests that CD40-dependent activation of B-cells is important for generation of memory B-cells within the germinal centers. Mutations of the gene for CD40 antigen result in HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 3. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
See Also