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Antigens, HLA B

Class I Human Histocompatibility (HLA) Surface Antigens encoded by more than 30 detectable Alleles on locus B of the HLA complex, the most polymorphic of all the HLA specificities. Several of these Antigens (e.g., HLA-B27, -B7, -B8) are strongly associated with predisposition to rheumatoid and other autoimmune disorders. Like other class I HLA determinants, they are involved in the cellular immune reactivity of cytolytic T Lymphocytes.