Apolipoprotein CIII

A 9-kDa protein component of Very-Low-Density Lipoproteins and Chylomicron Remnants. Apo C-III, synthesized in the liver, is an inhibitor of Lipoprotein Lipase. Apo C-III modulates the binding of Chylomicron Remnants and VLDL to receptors (Receptors, LDL) thus decreases the uptake of triglyceride-rich particles by the liver Cells and subsequent degradation. The normal Apo C-III is glycosylated. There are several polymorphic Forms with varying amounts of Sialic Acid (Apo C-III-0, Apo C-III-1, and Apo C-III-2).