Apoptosis-Inducing Factor

A flavoprotein that functions as a powerful antioxidant in the Mitochondria and promotes Apoptosis when released from the Mitochondria. In mammalian Cells AIF is released in response to pro-apoptotic protein members of the bcl-2 protein Family. It translocates to the Cell Nucleus and binds DNA to stimulate CASPASE-independent Chromatin condensation.