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Apoptosomes

Multimeric protein complexes formed in the Cytosol that play a Role in the activation of Apoptosis. They can occur when Mitochondria become damaged due to Cell stress and release Cytochrome c. Cytosolic Cytochrome c associates with Apoptotic Protease-Activating Factor 1 to form the apoptosomal protein complex. The apoptosome signals Apoptosis by binding to and activating specific Initiator Caspases such as Caspase 9.