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Apoptotic Protease Activating Factor 3

A long pro-domain caspase that contains a caspase recruitment domain in its pro-domain region. Caspase 9 is activated during Cell stress by Mitochondria-derived proapoptotic factors and by CARD Signaling Adaptor Proteins such as Apoptotic Protease-Activating Factor 1. It activates Apoptosis by cleaving and activating Effector Caspases.