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Apparent Mineralocorticoid Excess Syndrome

A Hereditary Disease characterized by childhood onset Hypertension, hypokalemic Alkalosis, and low Renin and Aldosterone Secretion. It results from a defect in the activity of the 11-beta-Hydroxysteroid Dehydrogenase Type 2 enzyme which results in inadequate conversion of Cortisol to Cortisone. The build up of unprocessed Cortisol to levels that stimulate Mineralocorticoid Receptors creates the appearance of having excessive Mineralocorticoids.