Aromatase
Synonyms
Androstenedione Aromatase
Aromatase, Androstenedione
CYP 19
CYP19
CYP19 Protein
Cytochrome P 450 CYP19
Cytochrome P-450 CYP19
Cytochrome P-450(AROM)
Cytochrome P450 19
Estrogen Synthase
Estrogen Synthetase
P450AROM
Protein, CYP19
An enzyme that catalyzes the desaturation (aromatization) of the ring A of C19 androgens and converts them to C18 estrogens. In this process, the 19-methyl is removed. This enzyme is membrane-bound, located in the endoplasmic reticulum of estrogen-producing cells of ovaries, placenta, testes, adipose, and brain tissues. Aromatase is encoded by the CYP19 gene, and functions in complex with NADPH-FERRIHEMOPROTEIN REDUCTASE in the cytochrome P-450 system.