Arylsulfatase A Deficiency Disease

An autosomal recessive Metabolic Disease caused by a deficiency of Cerebroside-Sulfatase leading to intralysosomal accumulation of cerebroside sulfate (Sulfoglycosphingolipids) in the Nervous System and other organs. Pathological features include diffuse demyelination, and metachromatically-Staining granules in many Cell types such as the Glial Cells. There are several allelic and nonallelic Forms with a variety of neurological symptoms.