c abl Proteins

Non-receptor Tyrosine Kinases encoded by the C-abl Genes. They are distributed in both the Cytoplasm and the nucleus. c-Abl plays a Role in normal Hematopoiesis especially of the myeloid lineage. Oncogenic transformation of c-abl arises when specific N-terminal Amino Acids are deleted, releasing the Kinase from negative Regulation.