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c erbB 2 Protein

A Cell surface Protein-Tyrosine Kinase Receptor that is found to be overexpressed in a significant number of Adenocarcinomas. It has extensive homology to and can heterodimerize with the EGF Receptor (Receptor, Epidermal Growth Factor), the erbB-3 Receptor (Receptor, erbB-3) and the erbB-4 receptor. Activation of the erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB receptor Family members.