c erbB 2 Proto Oncogenes
The erbB-2 Gene is a Proto-Oncogene that codes for the erbB-2 Receptor (Receptor, erbB-2), a protein with structural features similar to the Epidermal Growth Factor Receptor. Its name originates from the viral Oncogene homolog (v-erbB) which is a truncated form of the Chicken erbB Gene found in the Avian Erythroblastosis Virus. Overexpression and amplification of the Gene is associated with a significant number of Adenocarcinomas. The Human c-erbB-2 Gene is located at 17q21.2.