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c met Proteins

Cell surface Protein-Tyrosine Kinase Receptors for Hepatocyte Growth Factor. They consist of an extraCellular alpha chain which is disulfide-linked to the transmembrane beta chain. The cytoplasmic portion contains the Catalytic Domain and sites critical for the Regulation of Kinase activity. Mutations of the Gene for Proto-Oncogene Proteins C-MET are associated with papillary renal Carcinoma and other Neoplasia.