c rel Proteins

Cellular DNA-Binding Proteins encoded by the rel Gene (Genes, rel). They are expressed predominately in hematopoietic Cells and may play a Role in Lymphocyte differentiation. Rel frequently combines with other related Proteins (NF-kappa B, I-kappa B, relA) to form heterodimers that regulate transcription. Rearrangement or overexpression of c-rel can cause Tumorigenesis.