Calcium-dependent Cell Adhesion Proteins. They are important in the formation of Adherens Junctions between Cells. Cadherins are classified by their distinct immunological and Tissue specificities, either by letters (E- for epithelial, N- for neural, and P- for placental cadherins) or by numbers (cadherin-12 or N-cadherin 2 for Brain-cadherin). Cadherins promote Cell Adhesion via a homophilic mechanism as in the construction of Tissues and of the whole Animal body.