Cilastatin

Synonyms

2-Heptenoic acid, 7-((2-amino-2-carboxyethyl)thio)-2-(((2,2-dimethylcyclopropyl)carbonyl)amino)-, (R-(R*,S*-(Z)))-

Cilastatin Monosodium Salt

Cilastatin Sodium

MK 0791

MK 791

MK-791

MK0791

MK791

Monosodium Salt, Cilastatin

Salt, Cilastatin Monosodium

Sodium, Cilastatin

A renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, IMIPENEM, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to increase its effectiveness. The drug also inhibits the metabolism of leukotriene D4 to leukotriene E4.