Cisplatin

Synonyms

Biocisplatinum

Diamminodichloride, Platinum

Dichlorodiammineplatinum

NSC-119875

Platidiam

Platino

Platinol

Platinum Diamminodichloride

Platinum, diamminedichloro-, (SP-4-2)-

cis Diamminedichloroplatinum

cis Platinum

cis-Diamminedichloroplatinum

cis-Diamminedichloroplatinum(II)

cis-Dichlorodiammineplatinum(II)

cis-Platinum

An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.