Complement C8

Synonyms

C8 Complement

C8, Complement

Complement 8

Complement Component 8

Complement Component C8 alpha

Complement Component C8 alpha Chain

Complement Component C8 beta

Complement Component C8 beta Chain

Complement Component C8 gamma

Complement Component C8 gamma Chain

Complement, C8

Component 8, Complement

A 150-kDa serum glycoprotein composed of three subunits with each encoded by a different gene (C8A; C8B; and C8G). This heterotrimer contains a disulfide-linked C8alpha-C8gamma heterodimer and a noncovalently associated C8beta chain. C8 is the next component to bind the C5-7 complex forming C5b-8 that binds COMPLEMENT C9 and acts as a catalyst in the polymerization of C9.