Didanosine

Synonyms

2',3' Dideoxyinosine

2',3'-Dideoxyinosine

Bristol Myers Brand of Didanosine

Bristol Myers Squibb Brand of Didanosine

Bristol-Myers Brand of Didanosine

Bristol-Myers Squibb Brand of Didanosine

Dideoxyinosine

Inosine, 2',3'-dideoxy-

NSC 612049

NSC-612049

NSC612049

Videx

ddI (Antiviral)

A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase; ddI is then metabolized to dideoxyadenosine triphosphate, its putative active metabolite.