DNA Footprinting
Synonyms
DNA Footprint
DNA Footprintings
DNA Footprints
Footprint, DNA
Footprinting, DNA
Footprintings, DNA
Footprints, DNA
A method for determining the sequence specificity of DNA-binding proteins. DNA footprinting utilizes a DNA damaging agent (either a chemical reagent or a nuclease) which cleaves DNA at every base pair. DNA cleavage is inhibited where the ligand binds to DNA. (from Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)