DNA Probes
Synonyms
Chromosomal Probes
Chromosomal Probes, Whole
Conserved Gene Probes
DNA Gene Probes
DNA Hybridization Probes
Gene Probes, Conserved
Gene Probes, DNA
Hybridization Probes, DNA
Probes, Chromosomal
Probes, Conserved Gene
Probes, DNA
Probes, DNA Gene
Probes, DNA Hybridization
Probes, Whole Chromosomal
Whole Chromosomal Probes
Whole Genomic DNA Probes
Species- or subspecies-specific DNA (including COMPLEMENTARY DNA; conserved genes, whole chromosomes, or whole genomes) used in hybridization studies in order to identify microorganisms, to measure DNA-DNA homologies, to group subspecies, etc. The DNA probe hybridizes with a specific mRNA, if present. Conventional techniques used for testing for the hybridization product include dot blot assays, Southern blot assays, and DNA:RNA hybrid-specific antibody tests. Conventional labels for the DNA probe include the radioisotope labels 32P and 125I and the chemical label biotin. The use of DNA probes provides a specific, sensitive, rapid, and inexpensive replacement for cell culture techniques for diagnosing infections.
See Also