E Box Sites

DNA locations with the Consensus Sequence CANNTG. Enhancer Elements may contain multiple copies of this element. E-boxes play a regulatory Role in the control of transcription. They bind with basic helix-loop-helix (bHLH) type Transcription Factors. Binding specificity is determined by the specific bHLH heterodimer or homodimer combination and by the specific Nucleotides at the 3rd and 4th position of the E-box sequence.