Genes, erbB-1
Synonyms
EGFR Gene
EGFR Genes
Epidermal Growth Factor Receptor Genes
Gene, erbB1
Genes, EGFR
Genes, erbB1
c erbB 1 Genes
c erbB 1 Proto Oncogenes
c-erbB-1 Gene
c-erbB-1 Genes
c-erbB-1 Proto-Oncogene
c-erbB-1 Proto-Oncogenes
erbB 1 Genes
erbB-1 Gene
erbB-1 Genes
erbB1 Gene
erbB1 Genes
v erbB Genes
v erbB Oncogenes
v-erbB Gene
v-erbB Genes
v-erbB Oncogene
v-erbB Oncogenes
The proto-oncogene c-erbB-1 codes for the epidermal growth factor receptor. Its name originates from the viral homolog v-erbB which was isolated from an avian erythroblastosis virus (AEV) where it was contained as a fragment of the chicken c-ErbB-1 gene lacking the amino-terminal ligand-binding domain. Overexpression of erbB-1 genes occurs in a wide range of tumors, commonly squamous carcinomas of various sites and less commonly adenocarcinomas. The human c-erbB-1 gene is located in the chromosomal region 7p14 and 7p12.